| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000199211 |
| ISSN: | 0100-4042 |
| Autores: | Montanari, Maria Luiza C1 Montanari, Carlos A Gaudio, Anderson C |
| Instituciones: | 1Universidade Federal de Minas Gerais, Departamento de Química, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal do Espirito Santo, Departamento de Fisica, Vitoria, Espirito Santo. Brasil |
| Año: | 2002 |
| Periodo: | Mar-Abr |
| Volumen: | 25 |
| Número: | 2 |
| Paginación: | 231-240 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, descriptivo |
| Resumen en inglés | The comparative QSAR is a tool for validating any statistical model that seems to be reasonable in describing an interaction between a bioactive new chemical entity, BIONCE, and the biological system. In order to deeper the understanding of the relationships and the meaning of parameters within the model it is necessary some kind of lateral validation. This validation can be accomplished by chemical procedures using physicochemical organic reactions and by means of biological systems. In this paper we review some of such comparisons and also present a lateral validation between the same set of antimicrobial hydrazides acting against Saccharomyces cerevisiae yeast and Escherichia coli bacterium cells. QSARs are presented to shed light in this important way of stating that the QSAR model is not the endpoint, but the beginning |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Microbiología, Fisicoquímica y química teórica, Química farmacéutica, QSAR, Antimicrobianos, Saccharomyces cerevisiae, Escherichia coli, Hidrazidas, Validación, Validación lateral |
| Keyword: | Medicine, Chemistry, Microbiology, Medicinal chemistry, Physical and theoretical chemistry, QSAR, Antimicrobial agents, Saccharomyces cerevisiae, Escherichia coli, Hydrazides, Validation, Lateral validation |
| Texto completo: | Texto completo (Ver HTML) |
