| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313331 |
| ISSN: | 0100-4042 |
| Autores: | Ronsein, Graziella E1 Miyamoto, Sayuri Bechara, Etelvino Mascio, Paolo Di Martinez, Glaucia R2 |
| Instituciones: | 1Universidade de Sao Paulo, Instituto de Quimica, Sao Paulo. Brasil 2Universidade Federal do Parana, Setor de Ciencias Biologicas, Curitiba, Parana. Brasil |
| Año: | 2006 |
| Periodo: | Jun |
| Volumen: | 29 |
| Número: | 3 |
| Paginación: | 563-568 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Proteins are potential targets for singlet molecular oxygen (¹O2) oxidation. Damages occur only at tryptophan, tyrosine, histidine, methionine, and cysteine residues at physiological pH, generating oxidized compounds such as hydroperoxides. Therefore, it is important to understand the mechanisms by which ¹O2, hydroperoxides and other oxidized products can trigger further damage. The improvement and development of new tools, such as clean sources of ¹O2 and isotopic labeling approaches in association with HPLC/mass spectrometry detection will allow one to elucidate mechanistic features involving ¹O2-mediated protein oxidation |
| Disciplinas: | Química |
| Palabras clave: | Bioquímica, Proteínas, Oxígeno singulete, Peróxidos, Oxidación |
| Keyword: | Chemistry, Biochemistry, Proteins, Singlet oxygen, Peroxides, Oxidation |
| Texto completo: | Texto completo (Ver HTML) |
