| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313226 |
| ISSN: | 0100-4042 |
| Autores: | Barbosa, Livea Fujita1 Medeiros, Marisa H.G. de Augusto, Ohara |
| Instituciones: | 1Universidade de Sao Paulo, Instituto de Quimica, Sao Paulo. Brasil |
| Año: | 2006 |
| Periodo: | Nov |
| Volumen: | 29 |
| Número: | 6 |
| Paginación: | 1352-1360 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Accumulated evidence indicates that oxidative stress plays a role in neurodegenerative diseases, such as Alzheimer, Parkinson and Amyotrophic Lateral Sclerosis. Here, we emphasize the results provided by the technology of genetically modified animals. Studies with transgenic and knockout mice have allowed great advances in the research of oxidative stress in general and in the central nervous system, and are pointing to potential targets for the development of new drugs and therapies to disrupt the cycle of events that lead to neuronal death. Thus, genetically modified animals are a valuable tool for the comprehension of human diseases, including neurodegenerative ones |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Bioquímica, Medicina experimental, Neurología, Daño oxidativo, Neurodegeneración, Animales transgénicos |
| Keyword: | Chemistry, Medicine, Biochemistry, Experimental medicine, Neurology, Oxidative damage, Neurodegeneration, Transgenic animals |
| Texto completo: | Texto completo (Ver HTML) |
