| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000350543 |
| ISSN: | 0074-0276 |
| Autores: | Magalhaes, Ivna de Melo1 Martins, Rebeca Vazquez Novo1 Vianna, Renata Oliveira1 Moyses, Natalia1 Afonso, Larissa Alves1 Oliveira, Solange Artimos1 Cavalcanti, Silvia Maria Baeta1 |
| Instituciones: | 1Universidade Federal Fluminense, Instituto Biomedico, Niteroi, Rio de Janeiro. Brasil |
| Año: | 2011 |
| Periodo: | May |
| Volumen: | 106 |
| Número: | 3 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | In this study, we assessed the prevalence of human herpesvirus-7 (HHV-7) in 141 serum samples from children less than four years of age with exanthematic disease. All samples were negative for measles, rubella, dengue fever and parvovirus B19 infection. Testing for the presence of human herpesvirus-6 (HHV-6)-specific high avidity IgG antibodies by indirect immunofluorescence assay (IFA) revealed two main groups: one composed of 57 patients with recent primary HHV-6 infection and another group of 68 patients showing signs of past HHV-6 infection. Another 16 samples had indeterminate primary HHV-6 infection, by both IgG IFA and IgM IFA. Serum samples were subjected to a nested polymerase chain reaction to detect the presence of HHV-7 DNA. Among patients with a recent primary HHV-6 infection, HHV-7 DNA was present in 1.7% of individuals; however, 5.8% of individuals tested positive for HHV-7 DNA in the group with past primary HHV-6 infection. Among the 16 samples with indeterminate diagnosis, 25% (4/16) had HHV-7 DNA (p < 0.002). We hypothesise that HHV-7 might be the agent that causes exanthema. However, a relationship between clinical manifestations and the detection of virus DNA does not always exist. Therefore, a careful interpretation is necessary to diagnose a primary infection or a virus-associated disease. In conclusion, we detected HHV-7 DNA in young children from the state of Rio de Janeiro, Brazil |
| Disciplinas: | Medicina |
| Palabras clave: | Microbiología, Exantema súbito, Herpesvirus, Niños |
| Keyword: | Medicine, Microbiology, Exanthema subitum, Herpesvirus, Children |
| Texto completo: | Texto completo (Ver HTML) |
