HEMA/MMA/EDMA packing material evaluation for size exclusion chromatography (SEC)



Título del documento: HEMA/MMA/EDMA packing material evaluation for size exclusion chromatography (SEC)
Revista: Materials research
Base de datos: PERIÓDICA
Número de sistema: 000312797
ISSN: 1516-1439
Autores: 1
2
3
Instituciones: 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil
2Loma Linda University, School of Pharmacy, Loma Linda, California. Estados Unidos de América
3Temple University, School of Pharmacy, Filadelfia, Pensilvania. Estados Unidos de América
Año:
Periodo: Ene-Mar
Volumen: 8
Número: 1
Paginación: 15-21
País: Brasil
Idioma: Inglés
Tipo de documento: Nota breve o noticia
Enfoque: Experimental
Resumen en inglés HEMA/MMA/EDMA (2-hydroxyethyl methacrylate/methyl methacrylate/ethyleneglycol methacrylate) copolymer beads have been synthesized for use in aqueous SEC. This porous chromatographic support consisted of a large average particle size (250 µm) and contained macropores with a median pore size of approximately 880 Å. The material was packed in glass and stainless columns to assess their chromatographic performance. The packed columns were calibrated using narrow molecular weight (MW) distribution standards (dextran) and exhibited a range of molecular weight separation between 40,000 and 2,000,000 daltons. The packing material showed the ability to separate large molecules through the size exclusion mechanism
Disciplinas: Ingeniería,
Química,
Física y astronomía
Palabras clave: Ingeniería de materiales,
Química farmacéutica,
Química industrial,
Física atómica y molecular,
Polímeros,
Porosidad,
Propiedades químicas,
Embalaje,
Conservación,
Medicamentos
Keyword: Engineering,
Chemistry,
Physics and astronomy,
Materials engineering,
Industrial chemistry,
Medicinal chemistry,
Atomic and molecular physics,
Polymers,
Porosity,
Chemical properties,
Packing,
Conservation,
Drugs
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