| Revista: | Journal of the Mexican Chemical Society |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000447321 |
| ISSN: | 1870-249X |
| Autores: | Narasimha Raju, Pericherla V.S1 Rao Saketi, Jagan Mohana2 Balaji, Neduri V1 Kurmarayuni, Chandra Mohan2 Subbaraju, Gottumukkala V1 Bollikolla, Hari Babu2 |
| Instituciones: | 1Natsol Laboratories Private Limited, Visakhapatnam, Andhra Pradesh. India 2Acharya Nagarjuna University, Department of Chemistry, Ongole, Andhra Pradesh. India |
| Año: | 2021 |
| Periodo: | Abr-Jun |
| Volumen: | 65 |
| Número: | 2 |
| Paginación: | 237-246 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en español | Se prepararon 10 nuevas hispolon-pirazol-suklfonamidas con buenos rendimientos haciendo reaccionar hipolonas y el clorhidrato de 4-sulfonamidil-fenílhidrazina. Los productos obtenidos se probaron contra cepas de hongos y bacterias con especial interés en la tuberculosis, encontrando algunos derivados con actividades del orden de MIC 6.25µg/mL |
| Resumen en inglés | A series of 10 new hispolonpyrazole sulfonamides were designed and synthesized using hispolons and 4-sulfonamide phenylhydrazine hydrochloride with better yields. The synthesized pyrazole sulfonamides were screened for anti-TB, anti-bacterial, and anti-fungal activities to compare the role sulfonamide moiety. Among them, 3a and 3b showed selective potent anti-tubercular nature (MIC 6.25µg/mL). Further, the antimicrobial studies of the compounds showed only compound 3b with a good inhibition zone on Staphylococcus aureus among other bacteria and fungi studied |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Hispolón, Sulfonamidas, Pirazoles, Actividad antimicrobiana, Tuberculosis |
| Keyword: | Medicinal chemistry, Hispolon, Sulfonamides, Pyrazoles, Antimicrobial activity, Tuberculosis |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
