| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434848 |
| ISSN: | 1677-5538 |
| Autores: | Souza, Aline Costa de1 Gallo, Carla Braga Mano1 Passos, Magna Cottini da Fonseca2 Croccia, Carolina3 Miranda, Glauciane Lacerda3 Sampaio, Francisco José Barcellos1 Gregório, Bianca Martins1 |
| Instituciones: | 1Universidade do Estado do Rio de Janeiro, Centro Biomedico, Rio de Janeiro. Brasil 2Universidade do Estado do Rio de Janeiro, Instituto de Nutricao, Rio de Janeiro. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Nutricao Josue de Castro, Rio de Janeiro. Brasil |
| Año: | 2019 |
| Periodo: | Ene-Feb |
| Volumen: | 45 |
| Número: | 1 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | High-fat diet-induced obesity is associated with metabolic disorders. The Brazil nut has bioactive substances and has been used to control the damage caused by obesity in several organs. The work intended to show the damage caused by high-fat diet in the bladder wall and if the Brazil nut oil added to the diet could ameliorate or reverse this effect. Sixty-day-old rats were divided into two groups: C (control, n = 30) and HF (high-fat, n = 30) diets. At 90 days, 10 animals of each group were sacrificed. The others were divided into 4 groups: C and HF (animals that maintained their previous diet, n = 10 for each group) and C / Bno and HF / Bno (animals whose control or high-fat diet was supplemented by Brazil nut oil, n = 10 for each group). Sacrifice occurred at 120 days, and the bladders were removed and analyzed. Epithelial height was increased in the HF compared to the C group. In contrast, the C / Bno had a lower epithelial height compared to the others. The percentage of collagen between the detrusor muscle fibers was significantly greater in C / Bno, HF and HF / Bno than in control group. The HF had a larger muscle fiber diameter than the C group, while the C / Bno presented lower values than the HF and HF / Bno groups. HF diets induced bladder wall damage. These changes in the rat's bladder wall were partially reversed by the Bno |
| Disciplinas: | Medicina |
| Palabras clave: | Urología, Medicina experimental, Vejiga urinaria, Experimentos de alimentación, Grasas, Nuez de Brasil, Actividad biológica |
| Keyword: | Urology, Experimental medicine, Urinary bladder, Feeding experiments, Fat, Brazil nut, Biological activity |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
