| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459173 |
| ISSN: | 1415-4757 |
| Autores: | Dieter, Cristine1 Lemos, Natália Emerim1 Girardi, Eliandra1 Ramos, Denise Taurino1 Corrêa, Nathalia Rodrigues de Faria1 Canani, Luís Henrique1 Bauer, Andrea Carla1 Assmann, Taís Silveira1 Crispim, Daisy1 |
| Instituciones: | 1Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia e Metabologia, Porto Alegre, Rio Grande do Sul. Brasil |
| Año: | 2023 |
| Periodo: | Ene |
| Volumen: | 46 |
| Número: | 2 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Long non-coding RNAs (lncRNAs) are RNAs with >200 nucleotides that are unable to encode proteins and are involved in gene expression regulation. LncRNAs have a key role in many physiological and pathological processes and, consequently, they have been associated with several human diseases, including diabetes chronic complications, such as diabetes kidney disease (DKD). In this context, some studies have identified the dysregulation of the lncRNAs MALAT1 and TUG1 in patients with DKD; nevertheless, available data are still contradictory. Thus, the objective of this study was to compare MALAT1 and TUG1 expressions in urine of patients with type 1 diabetes mellitus (T1DM) categorized according to DKD presence. This study comprised 18 T1DM patients with DKD (cases) and 9 long-duration T1DM patients without DKD (controls). MALAT1 and TUG1 were analyzed using qPCR. Bioinformatics analyses were done to identify both lncRNA target genes and the signaling pathways under their regulation. The lncRNA MALAT1 was upregulated in urine of T1DM patients with DKD vs. T1DM controls (P = 0.007). The expression of lncRNA TUG1 did not differ between groups (P = 0.815). Bioinformatics analysis showed these two lncRNAs take part in metabolism-related pathways. The present study shows that the lncRNA MALAT1 is upregulated in T1DM patients presenting DKD |
| Disciplinas: | Medicina |
| Palabras clave: | Metabolismo y nutrición, Diabetes mellitus tipo 2, LncRNAs, MALAT1, Biomarcadores |
| Keyword: | Metabolism and nutrition, Diabetes mellitus type 1, LncRNAs, MALAT1, Biomarkers |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
