Revista: | Genetics and molecular biology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000417926 |
ISSN: | 1415-4757 |
Autores: | Wortmann, André Castagna1 Simon, Daniel2 Mazzoleni, Luiz Edmundo3 Sander, Guilherme Becker3 Francesconi, Carlos Fernando de Magalhaes3 Nabinger, Debora Dreher2 Grott, Camila Schultz2 Rech, Tassia Flores2 Mazzoleni, Felipe3 Lunge, Vagner Ricardo4 Bona, Laura Renata de3 Milbradt, Tobias Cancian3 Silveira, Themis Reverbel da1 |
Instituciones: | 1Universidade Federal do Rio Grande do Sul, Program in Sciences of Gastroenterology and Hepatology, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Luterana do Brasil, Human Molecular Genetics Laboratory, Canoas, Rio Grande do Sul. Brasil 3Hospital de Clinicas de Porto Alegre, Division of Gastroenterology, Porto Alegre, Rio Grande do Sul. Brasil 4Universidade Luterana do Brasil, Molecular Diagnostic Laboratory, Canoas, Rio Grande do Sul. Brasil |
Año: | 2018 |
Periodo: | Mar |
Volumen: | 41 |
Número: | 1 |
Paginación: | 92-97 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Caso clínico, analítico |
Resumen en inglés | Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Studies on the association between functional dyspepsia and ATH are scarce. This study aimed to evaluate whether ATH is associated with symptoms of functional dyspepsia. Patients fulfilling the Rome III diagnostic criteria for functional dyspepsia underwent genetic testing for ATH. Dyspeptic symptoms were evaluated and scored according to a validated questionnaire. The diagnostic criteria for ATH was a CC genotype for the -13910C/T polymorphism, located upstream of the lactase gene. The mean scores for dyspeptic symptoms were compared between patients with ATH and those with lactase persistence. A total of 197 functional dyspeptic patients were included in the study. Mean age was 47.7 years and 82.7% patients were women. Eighty-eight patients (44.7%) had a diagnosis of ATH. Abdominal bloating scores were higher in ATH patients compared to the lactase persistent patients (P=0.014). The remaining dyspeptic symptom scores were not significantly different between the two groups. The study results demonstrate an association between ATH and bloating in patients with functional dyspepsia |
Disciplinas: | Medicina |
Palabras clave: | Gastroenterología, Metabolismo y nutrición, Genética, Hinchazón, Dispepsia, Enfermedades gastrointestinales, Intolerancia a la lactosa, Polimorfismos de nucleótido único (SNPs) |
Keyword: | Gastroenterology, Metabolism and nutrition, Genetics, Bloating, Dyspepsia, Gastrointestinal diseases, Lactose intolerance, Single nucleotide polymorphism (SNPs) |
Texto completo: | Texto completo (Ver PDF) |