Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development
Título del documento: Evaluation of association of DRD2 TaqIA and -141C InsDel polymorphisms with food intake and anthropometric data in children at the first stages of development
Revista: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000420001
ISSN: 1415-4757
Autores: 1
2
3
4
4
Instituciones: 1Universidade Federal de Ciencias da Saude de Porto Alegre, Laboratorio de Biologia Molecular, Porto Alegre, Rio Grande do Sul. Brasil
2Universidade Federal de Ciencias da Saude de Porto Alegre, Programa de Pos-Graduacao em Biociencias, Porto Alegre, Rio Grande do Sul. Brasil
3Universidade do Vale do Rio dos Sinos, Curso de Nutricao, Sao Leopoldo, Rio Grande do Sul. Brasil
4Universidade Federal de Ciencias da Saude de Porto Alegre, Departamento de Ciencias Basicas da Saude, Porto Alegre, Rio Grande do Sul. Brasil
Año:
Periodo: Sep
Volumen: 41
Número: 3
Paginación: 562-569
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés The reward sensation after food intake may be different between individuals and variants in genes related to the dopaminergic system may indicate a different response in people exposed to the same environmental factors. This study investigated the association of Taq IA (rs1800497) and -141C InsDel (rs1799732) variants in DRD2/ANKK1 gene with food intake and adiposity parameters in a cohort of children. The sample consisted of 270 children followed until 7 to 8 years old. DNA was extracted from blood and polymorphisms were detected by PCR-RFLP analysis. Food intake and nutritional status were compared among individuals with different SNP genotypes. Children carrying the A1 allele ( Taq IA) had higher energy of lipid dense foods (LDF) when compared with A2/A2 homozygous children at 7 to 8 years old (GLM p =0.004; Mann Whitney p =0.005). No association was detected with -141C Ins/Del polymor- phism. To our knowledge, this is the first association study of the DRD2 Taq IA and -141C Ins/Del polymorphism with food intake and anthropometric parameters in children. DRD2 Taq IA polymorphism has been associated with a re- duction in D 2 dopamine receptor availability. Therefore, the differences observed in LDF intake in our sample may oc - cur as an effort to compensate the hypodopaminergic functioning
Disciplinas: Medicina
Palabras clave: Endocrinología,
Metabolismo y nutrición,
Pediatría,
Obesidad infantil,
Polimorfismo,
Gen DRD2,
Ingesta de alimentos
Keyword: Endocrinology,
Metabolism and nutrition,
Pediatrics,
Child obesity,
Polymorphism,
DRD2 gene,
Food intake
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