| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000346311 |
| ISSN: | 1415-4757 |
| Autores: | Fonseca, Marbella Maria1 Alarcon, Frank J.B2 Vasconcelos, Ana Tereza de2 Agnez-Lima, Lucymara Fassarela1 |
| Instituciones: | 1Universidade Federal do Rio Grande do Sul, Centro de Biociencias, Natal, Rio Grande do Norte. Brasil 2Ministerio da Ciencia e Tecnologia, Laboratorio Nacional de Computacao Cientifica, Petropolis, Rio de Janeiro. Brasil |
| Año: | 2007 |
| Periodo: | Abr |
| Volumen: | 30 |
| Paginación: | 290-295 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Nota breve o noticia |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | In this work, we predict a structural model for the RecA protein from M. synoviae (MsRecA) by theoretical homology modeling and evaluate the occurrence of polymorphisms in this protein within several isolates of this species. The structural model suggested for MsRecA conserves the main domains present in MtRecA and EcRecA. The L1 and L2 regions showed six and three amino acid substitutions, respectively, which apparently do not affect the conformation and function of MsRecA. The C-terminal domain is shorter than that found in EcRecA and MtRecA, which may increase its capacity to bind dsDNA and displace SSB, compensating the absence of recombination initiation enzymes. The MS59 isolate RecA sequence showed one polymorphism which does not affect its functions since these belong to the same physical-chemical group |
| Disciplinas: | Biología |
| Palabras clave: | Bacterias, Genética, Biología molecular, Modelos biológicos, Reparación de ADN, Proteínas RecA, Mollicutes, Recombinación genética, Mycoplasma synoviae |
| Keyword: | Biology, Bacteria, Genetics, Molecular biology, Biological models, DNA repair, RecA proteins, Mollicutes, Genetic recombination, Mycoplasma synoviae |
| Texto completo: | Texto completo (Ver HTML) |
