Utilization profile of enoxaparin in hospitalized patients with Chronic Kidney Disease in southern Brazil



Título del documento: Utilization profile of enoxaparin in hospitalized patients with Chronic Kidney Disease in southern Brazil
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451431
ISSN: 1984-8250
Autores: 1
2
Instituciones: 1Pontificia Universidade Catolica do Rio Grande do Sul, Hospital Universitario Sao Lucas, Porto Alegre, Rio Grande do Sul. Brasil
2Pontificia Universidade Catolica do Rio Grande do Sul, Faculdade de Farmacia, Porto Alegre, Rio Grande do Sul. Brasil
Año:
Volumen: 56
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Chronic Kidney Disease (CKD) patients usually require the use of anticoagulants for treatment or prevention of thromboembolic diseases. One such commonly used anticoagulant is enoxaparin. However, special attention is advised when using this drug for CKD patients because dosage adjustments may be needed. This prospective observational study was conducted in adult patients (> 18 years) with CKD stages 3 to 5 who were followed-up daily via prescriptions, medical records and laboratory tests. Enoxaparin doses, renal function and adverse drug events (ADEs) were thus monitored. Of the 87 ADEs identified in this study, 56 (64.3%) occurred in patients requiring enoxaparin prescription adjustment. Out of the 9 patients who had severe ADEs, 8 (88.9%) needed enoxaparin prescription adjustment. The results of this study suggest an overall increased risk of major bleeding and ADEs in patients requiring enoxaparin prescription adjustment. Further investigation of alternative dosing regimens in patients with CKD to maintain efficacy while reducing risks is imperative, as are studies on the utility of monitoring anti-factor Xa activity to guide dosing of enoxaparin. In addition, the role of clinical pharmacists in the management of CKD patients is crucial, as dose adjustments are often necessary
Disciplinas: Medicina
Palabras clave: Farmacología,
Hospitales,
Nefrología,
Enfermedad renal crónica,
Anticoagulantes,
Enoxaparina,
Monitoreo farmacológico
Keyword: Pharmacology,
Nephrology,
Hospitals,
Chronic kidney disease,
Anticoagulants,
Enoxaparin,
Pharmacological screening
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