Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451291 |
ISSN: | 1984-8250 |
Autores: | Samimi, Zahra1 Kardideh, Bahareh1 Chalabi, Maryam1 Zafari, Parisa2 Taghadosi, Mahdi1 |
Instituciones: | 1Kermanshah University of Medical Sciences, Medical School, Kermanshah. Irán 2Mazandaran University of Medical Sciences, Faculty of Medicine, Sarí, Mazandarán. Irán |
Año: | 2020 |
Volumen: | 56 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | We performed this study to measure the Tumor Necrosis Factor-alpha (TNF-α) plasma level and to survey its correlation with disease activity in the newly diagnosed Rheumatoid Arthritis (RA) patients and those who were under treatment with the combination of Disease-Modifying Anti-Rheumatic Drug (DMARD) plus Prednisolone (PSL).We enrolled 30 newly diagnosed RA patients who received no treatment regarding their disease, 30 patients under treatment with the combination of Methotrexate (MTX) + Hydroxychloroquine (HCQ) + PSL and 30 healthy subjects in this case-control study from September 2017 to December 2017. The level of plasma TNF-α was measured by enzyme-linked immunosorbent assay (ELISA) in each group. For assessment of disease severity, we used Disease Activity Score-28 (DAS-28) formula, and regarding DAS-28, we divided patients into four groups, including remission, low, moderate and high disease activity. There were no significant differences in the plasma level of TNF-α between the newly diagnosed RA patients and subjects who received MTX + HCQ + PSL, as well as healthy controls (p>0.05). There was a significant correlation between plasma levels of TNF-α and DAS-28 in the newly diagnosed patients with RA (r = 0.594, P = 0.001). Targeting TNF-α at the early stage of RA could have more beneficial effects on the amelioration of disease activity |
Disciplinas: | Medicina |
Palabras clave: | Reumatología, Farmacología, Artritis reumatoide, Antirreumáticos, Factor de necrosis tumoral |
Keyword: | Rheumatology, Pharmacology, Rheumatoid arthritis, Antirheumatics, Tumor necrosis factor |
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