| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451243 |
| ISSN: | 1984-8250 |
| Autores: | Gonçalves, Melissa Marques1 Carneiro, Jaqueline1 Justus, Barbara1 Espinoza, Joel Toribio1 Budel, Jane Manfron1 Farago, Paulo Vitor1 Paula, Josiane Padilha de1 |
| Instituciones: | 1Universidade Estadual de Ponta Grossa, Programa de PosGraduacao em Ciencias Farmaceuticas, Ponta Grossa, Parana. Brasil |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Antibacterial activity and good mechanical properties are some of the characteristics required for an appropriate film dressing. A novel polymer blend was developed for wound healing application. Twenty-four formulations using the polymers chitosan, poly(vinyl alcohol) and/or ɛ-Polylysine and the plasticizer glycerol were designed using factorial design and then the films were prepared by the casting/solvent evaporation method. Seventeen films were obtained among the twenty-four proposed formulations that were characterized by Field Emission Scanning Electron Microscopy (FE-SEM) and Fourier Transform Infrared Spectroscopy (FTIR). Mechanical properties, such as tensile strength (σ), elongation at break (ɛ) and Young’s modulus (Y) as well as antibacterial properties were determined. The best candidate was then further analyzed with regard to porosity, Water Vapor Transmission Rate (WVTR), swelling and cytotoxicity experiments. The results showed a film with semi-occlusive characteristics, good mechanical properties and no toxic. Incorporation of ɛ-Polylysine increased antibacterial activity against gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) bacteria |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Microbiología, Películas antimicrobianas, Apósitos, Quitosano, Polilisina |
| Keyword: | Pharmacology, Microbiology, Antimicrobial films, Wound dressings, Chitosan, Polylysine |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
