Myricitrin and Its Solid Lipid Nanoparticle Increase Insulin Secretion and Content of Isolated Islets from the Pancreas of Male Mice
Título del documento: Myricitrin and Its Solid Lipid Nanoparticle Increase Insulin Secretion and Content of Isolated Islets from the Pancreas of Male Mice
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451776
ISSN: 1984-8250
Autores: 1
2
Instituciones: 1Ahvaz Jundishapur University of Medical Sciences, Health Research Institute, Ahvaz. Irán
2Dezful University of Medical Sciences, Faculty of Medicine, Dezful. Irán
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Glucose exposure induces toxic effects on the function of the pancreatic islets. Moreover, myricitrin as a flavonoid glycoside may have favorable effects on insulin secretion of Langerhans islets. The present study aimed to investigate the effect of Myricitrin and its solid lipid nanoparticles (SLN) on the insulin secretion as well as the content of isolated pancreatic islets from male mice. In this experimental study, Langerhans islets were separated from adult male NMRI mice using the collagenase method. The insulin secretion and content of islets were assessed in glucose-containing medium (2.8, 5.6, and 16.7mM). Further, islets treated were prepared by the administration of Myricitrin and its SLN (1, 3 and 10µM). Myricitrin 3μM, and SLN containing Myricitrin 3 and 10μM increased insulin secretion in medium containing glucose concentration 2.8mM. Accordingly, this variable increased in Myricitrin 3 and 10μM, SLN containing Myricitrin 1, 3, and 10μM utilization as well as glucose concentration 5.6mM. Afterward, the insulin secretion increased in medium containing 16.7mM glucose after the addition of Myricitrin and SLN containing Myricitrin 1, 3, and 10μM. Also, the insulin content increased in Myricitrin and SLN containing Myricitrin 1, 3, and 10μM administered groups in all medium containing glucose concentrations. Myricitrin and its SLN increased islets insulin secretion and content in low, moderate, and high glucose concentration mediums
Disciplinas: Química,
Medicina
Palabras clave: Farmacología,
Medicina experimental,
Endocrinología,
Diabetes,
Insulina,
Nanopartículas lípidas sólidas,
Miricitrina,
Isletas pancreáticas,
Ratones
Keyword: Pharmacology,
Experimental medicine,
Endocrinology,
Diabetes,
Myricitrin,
Solid lipid nanoparticles,
Pancreatic islets,
Insulin,
Mice
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