| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451261 |
| ISSN: | 1984-8250 |
| Autores: | Freire, Juliana Mesquita1 Barroso, Amanda Ribeiro1 Assis, Amanda Araujo de1 Texeira, Bruna Helena1 Braga, Jonatas Henrique Guimarães2 Oliveira, Daniela Aparecida1 Braga, Mariana Aparecida1 Marcussi, Silvana1 |
| Instituciones: | 1Universidade Federal de Lavras, Departamento de Quimica, Lavras, Minas Gerais. Brasil 2Universidade Federal de Lavras, Departamento de Ciencia dos Alimentos, Lavras, Minas Gerais. Brasil |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | The processing of grapes for the manufacture of juices and wines, generates large quantities of by-products rich in metabolites with antioxidant, antimicrobial, anti-inflammatory and cicatrizing activities. The high homology between human enzymes and snake venoms makes the latter valuable laboratory tools for the study of pathophysiological processes. Proteases and phospholipases A2 act in processes related to hemostasis and inflammatory response. Thus, in this work, dried pomace obtained from grape (Isabel, Niagara, Bordô, BRS Violeta and Blend cultivars) processing were evaluated on phospholipase, proteolytic, hemolytic and thrombolytic activities induced by snakes venoms and the content of phenolic compounds and minerals was evaluated. The dried pomace exerted inhibitory and potentiating actions in all analyzed activities. The enzymatic modulators present in the evaluated dried pomace have potential for therapeutic use, although their broad characterization is still necessary, in order to define adequate amounts and formulations to obtain efficacy and safety in their use |
| Disciplinas: | Química |
| Palabras clave: | Fitoquímica, Residuos agroindustriales, Orujo de uva, Compuestos fenólicos, Modulación enzimática, Proteasas |
| Keyword: | Phytochemistry, Agroindustrial wastes, Grape pomace, Phenolic compounds, Enzyme modulation, Proteases |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
