| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452193 |
| ISSN: | 1984-8250 |
| Autores: | Han, Song Chan1 Yun, Young Hak1 |
| Instituciones: | 1Kim Il Sung University, Pyongyang Medical College, Pyongyang. República Popular Democrática de Corea |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | We were carried out to investigate the efficacy of Rape (Rapeseed, Brassica napus L.) flower on BPH (benign prostatic hyperplasia) in rats. We found that the extract from Rape flower prevented hyperplasia in testosterone-induced BPH model, the relevant animal model of human BPH. Extract reduced the weight of prostate and induced significantly cell apoptosis in prostate in BPH model. In addition, the extract controlled expression of TGF-β1 in prostate gland and promoted urinary output in dose-dependence in BPH model. Our data provide that Rape flower may be useful for treatment of BPH |
| Disciplinas: | Química |
| Palabras clave: | Farmacología, Hiperplasia prostática, Ratas, Brassica napus, Brassicaceae |
| Keyword: | Pharmacology, Prostatic hyperplasia, Rats, Brassica napus, Brassicaceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
