| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451220 |
| ISSN: | 1984-8250 |
| Autores: | Santana, George Misael Ferreira de1 Santana, Danielle Cristine Almeida Silva de2 Santana, Fernando José Malagueño de1 |
| Instituciones: | 1Universidade Federal de Pernambuco, Hospital das Clinicas, Recife, Pernambuco. Brasil 2Universidade Federal de Pernambuco, Departamento de Ciencias Farmaceuticas, Recife, Pernambuco. Brasil |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Diabetes was investigated as a risk factor for nephrotoxicity induced by vancomycin. In the present study, the drug’s nephrotoxic effect was indirectly evaluated by Glomerular Filtration Rate, albuminuria and serum levels of creatinine and urea on the 1st, 7th and 14th days of vancomicyn therapy in a group of diabetic and non-diabetic patients, with and without previous nephropathy. The correlations between investigated variables (including the population’s epidemiological profile and hospital care) were measured by the Spearman test. The sample consisted of 132 patients, predominantly male diabetic patients with previous nephropathy, over 40 years, receiving ≥ 10 grams of vancomycin for the treatment of infectious diseases and showing satisfactory clinical outcomes. A risk of vancomycin drug interaction with potential nephrotoxic outcome was observed in 36.4% of patients who used multiple drugs. Furthermore, 80% of patients had an increase of at least 0.5 mg.dL-1 in baseline serum levels of creatinine and urea at the end of the study. This was more common among the diabetic patients with previous nephropathy, showing higher albuminuria and a reduction in the Glomerular Filtration Rate. Therefore, it has been recommended that the use of vancomycin in diabetic patients should be in careful dosages and that kidney functioning be monitored |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Nefrología, Farmacología, Lesión renal aguda, Vancomicina, Nefrotoxicidad, Diabetes mellitus, Sinergismo |
| Keyword: | Nephrology, Pharmacology, Acute kidney injury, Vancomycin, Nephrotoxicity, Diabetes mellitus, Synergism |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
