Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein
Título del documento: Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000452242
ISSN: 1984-8250
Autores: 1
1
4
2
3
1
Instituciones: 1Prince of Songkla University, Faculty of Traditional Thai Medicine, Hat-Yai, Songkhla. Tailandia
2Prince of Songkla University, Faculty of Medicine, Hat-Yai, Songkhla. Tailandia
3Prince of Songkla University, Faculty of Science, Hat-Yai, Songkhla. Tailandia
4Princess of Naradhiwas University, Faculty of Medicine, Mueang Narathiwat, Narathiwat. Tailandia
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged male rats for six weeks; control rats received distilled water. Compared to controls, CMP caused decreased body fat and lipid accumulation in liver cells and the platelet count. CMP did not affect basal blood pressure or heart rate in anesthetized rats. Vascular responsiveness to phenylephrine, DL-propargylglycine (PAG), acetylcholine or sodium nitroprusside was unaffected, but vasorelaxation to glyceryl trinitrate (GTN) increased. Effects of ODQ on vasorelaxation to GTN were similar in both groups. Expression of blood vessel eNOS, CSE and sGC was normal. The cyclic guanosine monophosphate (cGMP) level of CMP-treated rats was normal but addition of GTN increased cGMP and NO concentration more in CMP-treated rats than in controls, an effect unaltered by addition of diadzin. Taken together, CMP appears partially responsible for the improvement in cardiovascular health markers caused by coconut milk in middle-aged male rats
Disciplinas: Química
Palabras clave: Química de alimentos,
Leche de coco,
Proteínas,
Gliceril trinitrato,
Salud cardiovascular
Keyword: Food chemistry,
Coconut milk,
Proteins,
Glyceryl trinitrate,
Cardiovascular health
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