| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451963 |
| ISSN: | 1984-8250 |
| Autores: | Arslan, Ayşe Kübra Karaboğa1 Paşayeva, Leyla1 Tugay, Osman2 |
| Instituciones: | 1Erciyes University, Faculty of Pharmacy, Kayseri. Turquía 2Selcuk University, Faculty of Pharmacy, Konya. Turquía |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Increasing biological activity and phytochemical investigations on Eryngium species showed its potential as pharmaceutical approach. Eryngium kotschyi Boiss. is one of the species of Eryngium genus and is endemic to Turkey. It is known that this plant is traditionally used in the South-western part of Turkey for the treatment of various diseases. This study focuses on cytotoxic activities of methanol extract and ethyl acetate, n-butanol and water sub-extracts from E. kotschyi in A549, COLO 205 and MDA-MB-231 cell lines by Sulforhodamin B assay and qualitative and quantitative determination of phytochemical constituents in active extract by LC-MS/MS. From the result of the study, it was seen that E. kotschyi ethyl acetate (EKE) sub-extract showed the strongest cytotoxic effect with the low IC50 values (50.00; 31.96 and 22.26 μg/mL in A549; COLO 205 and MDA-MB-231 cells at 48 h, respectively). Preliminary examination of the mass spectrums revealed the presence of 15 phytochemical compounds in active sub-extract and 7 of them was quantified. According to quantitative analyses the main compounds of EKE sub-extract were rosmarinic acid (485.603 µg/mgextract), chlorogenic acid (62.355 µg/mgextract) and caffeic acid (59.266 µg/mgextract). Moreover, this preliminary study on inhibitory activity of EKE sub-extract suggests further toxicologic investigations and detailed investigation on cytotoxic effect of various combinations of determined compounds |
| Disciplinas: | Química, Biología |
| Palabras clave: | Fitoquímica, Angiospermas, Plantas medicinales, Citotoxicidad, Eryngium kotschyi, Apiaceae |
| Keyword: | Phytochemistry, Angiosperms, Medicinal plants, Cytotoxicity, Eryngium kotschyi, Apiaceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
