| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451855 |
| ISSN: | 1984-8250 |
| Autores: | Todorović, Kosta1 Stojiljković, Nenad1 Ilić, Sonja1 Stojanović, Nikola M1 Todorović, Ana1 Stojnev, Slavica1 Mitić, Aleksandar1 Spasić, Milan1 Jovanović, Marija1 |
| Instituciones: | 1University of Nis, Faculty of Medicine, Nis. Serbia |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Curcumin is a plant-derived compound with polypharmacological properties that are hampered by its poor solubility, fast degradation, etc. Wound closure complications that follow tooth extraction are numerous, and relatively frequently additional treatment is needed to prevent unwanted process chronification. The present study aims to compare the effects of free and the nanoliposome-encapsulated curcumin on tooth extraction wound closure. The experiments were performed on Wistar rats where both forms of curcumin were applied topically on a tooth extraction wound for seven days. Changes in tissue oxidative stress (malondialdehyde and oxidized proteins concentrations, and catalase activity) and inflammation (nitric oxide levels and myeloperoxidase activity) related parameters were studied three and seven days following the tooth extraction. Also, the extent of pathohistological changes and osteopontin immunohistochemical expression were studied. The obtained results indicate that both forms of curcumin prevent an increase in oxidative stress and inflammation-related parameters in the studied samples at 3-and 7-day time points. Additionally, we found that curcumin diminished tissue inflammatory response and osteopontin expression, while at the same time it caused faster granulation tissue maturation. The encapsulation of curcumin in nanoliposomes proved to be better in improving the extraction wound healing process than the free curcumin, giving this formulation a potential in the pharmaceutical industry |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Odontología, Farmacología, Extracción dental, Inflamación, Curcumina, Nanoliposomas |
| Keyword: | Dentistry, Pharmacology, Tooth extraction, Inflammation, Curcumin, Nanoliposomes |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
