| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451823 |
| ISSN: | 1984-8250 |
| Autores: | Jesus, Carlos Henrique Alves1 Scarante, Franciele Franco1 Schreiber, Anne Karoline1 Gasparin, Aléxia Thamara1 Redivo, Daiany Darlly Bello1 Rosa, Evelize Stacoviaki1 Cunha, Joice Maria da1 |
| Instituciones: | 1Universidade Federal do Parana, Departamento de Farmacologia, Curitiba, Parana. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Neuropathic pain (NP) affects more than 8% of the global population. The proposed action of the transient receptor potential ankyrin 1 (TRPA1) as a mechanosensor and the characterization of the transient receptor potential melastatin 8 (TRPM8) as a cold thermosensor raises the question of whether these receptors are implicated in NP. Our study aimed to evaluate the involvement of TRPA1 and TRPM8 in cold and mechanical signal transduction to obtain a comparative view in rat models of streptozotocin-induced diabetes (STZ) and chronic constriction injury of the sciatic nerve (CCI). The electronic von Frey test showed that STZ rats presented mechanical allodynia that was first evidenced on the 14th day after diabetes confirmation, and four days after CCI. This phenomenon was reduced by the intraplantar (ipl) administration of a TRPA1 receptor antagonist (HC-030031; 40 μL/300 μg/paw) in both NP models. Only CCI rats displayed cold hyperalgesia based on the cold plate test. The pharmacological blocking of TRPA1 through the injection of the antagonist attenuated cold hyperalgesia in this NP model. STZ animals showed a reduction in the number of flinches induced by the intraplantar injection of mustard oil (MO; TRPA1 agonist; 0.1%/50 μL/paw), or intraplantar injection of menthol (MT; TRPM8 agonist; 0.5% and 1%/50 μL/paw). The response induced by the ipl administration of MT (1%/50 µL/paw) was significantly different between the CCI and SHAM groups. Together, these data suggest a different pattern in nociceptive behavior associated with different models of NP, suggesting a variant involvement of TRPA1 and TRPM8 in both conditions |
| Disciplinas: | Medicina |
| Palabras clave: | Neurología, Endocrinología, Diabetes, Dolor neuropático, Constricción nerviosa crónica, Nervio ciático, Hiperalgesia por frío, Alodinia mecánica |
| Keyword: | Neurology, Endocrinology, Diabetes, Neuropathic pain, Chronic constriction injury, Sciatic nerve, Mechanical allodynia, Cold hyperalgesia |
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