| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451728 |
| ISSN: | 1984-8250 |
| Autores: | Fonseca, Juliane Morais da1 Reis, Adriana Cotta Cardoso1 Pereira, Guilherme Rocha2 Moura, Hélia Maria Marques de1 Souza, José Dias1 Silva, Breno de Mello3 Brandao, Geraldo Célio1 |
| Instituciones: | 1Universidade Federal de Ouro Preto, Escola de Farmacia, Ouro Preto, Minas Gerais. Brasil 2Pontificia Universidade Catolica de Minas Gerais, Instituto de Ciencias Exatas e Tecnologia da Informacao, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal de Ouro Preto, Instituto de Ciencias Exatas e Biologicas, Ouro Preto, Minas Gerais. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography-ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were detected and characterized on the basis of their fragmentation pattern in the positive and negative ion mode tandem mass spectrometry spectra and ultraviolet bands. Acacetin, chrysin, vitexin, isovitexin, orientin, isoorientin, mangiferin, 2’-O-trans-caffeoylmangiferin, 2’-O-trans-coumaroylmangiferin and 2’-O-trans-cinnamoylmangiferin were identified by comparison with authentic samples. The other compounds detected were tentatively assigned by analysis of the spectral data and by comparison with literature reports. In addition, it performed the fractionation of the leaves extract leading to the isolation of mangiferin, isovitexin and isoorientin. All extracts and isolated compounds inhibited the Dengue virus replication cycle with EC50 less than 25.0 µg/mL for extracts and 272.5, 85.6 and 79.3 µg/mL for mangiferin, isovitexin and isoorientin, respectively |
| Disciplinas: | Química |
| Palabras clave: | Fitoquímica, Microbiología, Xantonas, Flavonoides, Actividad antiviral, Dengue, Fridericia samydoides, Bignoniaceae |
| Keyword: | Phytochemistry, Microbiology, Xanthones, Flavonoids, Antiviral activity, Dengue, Fridericia samydoides, Bignoniaceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
