Chemical and biological properties of nordihydroguaiaretic acid
Título del documento: Chemical and biological properties of nordihydroguaiaretic acid
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000452064
ISSN: 1984-8250
Autores: 1
1
1
Instituciones: 1Universidade Estadual do Centro-Oeste, Laboratorio de Nanotecnologia Farmaceutica, Guarapuava, Parana. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Nordihydroguaiaretic acid (NDGA) is a natural product obtained by the alkaline extraction of dried plants of Larrea tridentata species. Due to the biological properties presented, such as antioxidant, anti-inflammatory, antiviral and cytotoxic capacity, this compound is being increasingly studied. In this review, it was evaluated the benefits of NDGA against different animal models. Besides that, it was found that this compound has antitumor activity similar to its synthetic derivative terameprocol in prostate tumors. The hypoglycemic effect may be evidenced by the inhibition of sugar uptake by NDGA; in obesity, studies have observed that NDGA presented a positive regulatory effect for Peroxisome proliferator-activated receptors (PPAR-α) involved in the oxidation of hepatic fatty acids and reduced the expression of lipogenic genes. Regarding its antioxidant potential, its mechanism is related to the ability to in vitro scavenging reactive substances. Although there are several studies demonstrating the benefits of using NDGA, there are also reports of its toxicity, mainly of liver damage and nephrotoxicity
Disciplinas: Química
Palabras clave: Fitoquímica,
Farmacología,
Productos naturales,
Acido nordihidroguayarético,
Actividad biológica,
Larrea tridentata,
Zygophyllaceae
Keyword: Phytochemistry,
Pharmacology,
Natural products,
Nordihydroguaiaretic acid,
Biological activity,
Larrea tridentata,
Zygophyllaceae
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