Association of reproductive risk factors and comorbidities among molecular subtypes of Breast cancer in a Tertiary care Hospital
Título del documento: Association of reproductive risk factors and comorbidities among molecular subtypes of Breast cancer in a Tertiary care Hospital
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000452192
ISSN: 1984-8250
Autores: 1
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2
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Instituciones: 1The Tamilnadu Dr.M.G.R Medical University, PSG College of Pharmacy, Chennai, Tamil Nadu. India
2PSG Hospitals, Department Oncology, Coimbatore, Tamil Nadu. India
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The reasons for the recently observed increase in the incidence of breast cancer in the Indian population are not clearly understood, but thought to be largely explained by westernization of lifestyles and changes in reproductive behavior, which characterize exposure to hormones. Our aim is to review the reproductive risk factors and comorbidities and evaluate the association between molecular subtypes of breast cancer. A hospital-based analytical case-control study was conducted among the breast cancer cases with controls in a multispecialty teaching hospital for a period of one year. Totally, 130 subjects were recruited and an interview was conducted using a structured questionnaire to obtain demographic and risk factor data, including tissue marker status (ER, PR and HER-2) obtained from case files. Data were analyzed with SPSS-20 version. Results: The highest age group reported in this study was 51- 60 years which has a 3.8 times increased risk compared to other age and the age group of 31- 40 have a decrease risk of 0.33. In this study, the percentage of post menopause (68%) and mothers not breastfeeding (10%) was higher in cases compared to controls and a noted increase in the risk of breast cancer with odds ratio (OR) of 2.745 (p= <0.0001) and 9.08 (p=0.01) respectively. Duration of breastfeeding showed significantly (p=<0.0001)) moderate positive correlation (r=0.549, 0.457, 0.418 and 0.636) for luminal A, luminal B, HER+, and triple negative respectively. This study found that all the reproductive risk factors do not have correlation with a molecular subtype of breast cancer except breastfeeding. Post menopause and breastfeeding were common factors associated with all people and could be modifiable to prevent the occurrence of breast cancer through lifestyle changes
Disciplinas: Medicina
Palabras clave: Oncología,
Ginecología y obstetricia,
Diagnóstico,
Cáncer,
Mama,
Riesgo reproductivo,
Comorbilidad,
Receptores hormonales,
Marcadores moleculares
Keyword: Oncology,
Gynecology and obstetrics,
Diagnosis,
Cancer,
Breast,
Reproductive risk,
Comorbidity,
Hormonal receptors,
Molecular markers
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