| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452228 |
| ISSN: | 1984-8250 |
| Autores: | Oliveira, Bárbara Gonçalves de1 Santos, Luiz Filipe Ferreira1 Costa, Marliete Carvalho da2 Bastos, Rafael Wesley2 Carmo, Paulo Henrique Fonseca do2 Santos, Daniel de Assis2 Pianetti, Gérson Antônio1 César, Isabela Costa1 |
| Instituciones: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The use of Echinacea purpurea (EP), a plant native from North America, is widely diffused throughout the world, presenting many pharmacological applications, mainly for the treatment of infections of respiratory and urinary tracts. Due to the widespread commercialization of EP-based products, an effective evaluation of their pharmacological properties is essential to assure efficacy during clinical use. In this study, in vitro tests were performed to evaluate the antimicrobial activity of dried extracts of EP by the microdilution method. In addition, a phagocytosis model was employed to assess the immunomodulatory potential of the extracts. The increase in reactive oxygen species production, as well as the intracellular proliferation rate of Cryptococcus gatti after phagocytosis by macrophages in the presence of EP dried extracts were also evaluated. The analyzed samples showed no significant antibacterial activity; however, a slight antifungal activity was verified. Positive effects of EP extracts on the modulation of cellular immune response were observed in different experiments, indicating that this mechanism may contribute to the control and treatment of infections |
| Disciplinas: | Química |
| Palabras clave: | Farmacología, Fitoquímica, Acido cafeico, Actividad antimicrobiana, Inmunomodulación, Echinacea purpurea, Asteraceae |
| Keyword: | Pharmacology, Phytochemistry, Caffeic acid, Antimicrobial activity, Immunomodulation, Echinacea purpurea, Asteraceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
