A hybrid feedforward neural network model for the cephalosporin C production process



Título del documento: A hybrid feedforward neural network model for the cephalosporin C production process
Revista: Brazilian journal of chemical engineering
Base de datos: PERIÓDICA
Número de sistema: 000308660
ISSN: 0104-6632
Autores: 1



Instituciones: 1Universidade Federal de Sao Carlos, Departamento de Engenharia Quimica, Sao Carlos, Sao Paulo. Brasil
Año:
Periodo: Dic
Volumen: 17
Número: 4-7
Paginación: 587-598
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés At present, direct on-line measurements of key bioprocess variables as biomass, substrate and product concentrations is a difficult task. Many of the available hardware sensors are either expensive or lack reliability and robustness. To overcome this problem, indirect estimation techniques have been studied during the last decade. Inference algorithms rely either on phenomenological or on empirical models. Recently, hybrid models that combine these two approaches have received great attention. In this work, a hybrid neural network algorithm was applied to a fermentative process. Mass balance equations were coupled to a feedforward neural network (FNN). The FNN was used to estimate cellular growth and product formation rates, which are inserted into the mass balance equations. On-line data of cephalosporin C fed-batch fermentation were used. The measured variables employed by the inference algorithm were the contents of CO2 and O2 in the effluent gas. The fairly good results obtained encourage further studies to use this approach in the development of process control algorithms
Disciplinas: Química
Palabras clave: Fermentaciones,
Química farmacéutica,
Redes neuronales,
Modelos híbridos,
Cefalosporina C,
Bioproducción,
Inferencia de estado
Keyword: Chemistry,
Fermentation,
Medicinal chemistry,
Neural networks,
Hybrid models,
Cephalosporin C,
Bioproduction,
Inference of state
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