Lipopolysaccharide-stimulated intracellular cytokines and depressive symptoms in community-dwelling older adults



Título del documento: Lipopolysaccharide-stimulated intracellular cytokines and depressive symptoms in community-dwelling older adults
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000431159
Autores: 1
2
1
1
Instituciones: 1University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, California. Estados Unidos de América
2Western University of Health Sciences, Pomona, California. Estados Unidos de América
Año:
Periodo: Sep-Oct
Volumen: 46
Número: 5
Paginación: 137-140
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Inflammation is involved in the pathophysiology of depression, and circulating inflammatory cytokines have been associated with depressive symptoms. However, measuring circulating cytokines have inherent methodological limitations. In vitro lipopolysaccharide (LPS)-stimulated intracellular cytokines (ICCs) overcome these limitations. Furthermore, because psychosocial and physiological stressors activate inflammatory responses and LPS-stimulated ICCs reflect the inflammatory responsivity of monocytes to such stressors, ICCs may reflect individual stress responsivity. Methods This cross-sectional study examined whether LPS-stimulated expression of ICCs in peripheral blood mononuclear cells (PBMCs) is a sensitive inflammation measure correlated with depressive symptoms in 180 community-dwelling older adults. We tested correlations of not only intracellular but also circulating inflammatory markers with depressive symptoms assessed using the 10-item Center for Epidemiological Studies Depression Scale (CES-D). Intracellular markers included expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and both in PBMCs. Circulating markers included IL-6, TNF-α, and C-reactive protein (CRP) in plasma. Results None of the correlations were statistically significant. However, in contrast to circulating markers, the correlations of ICCs were consistently in the expected direction, i.e., higher ICC expression correlating with higher depression severity. Discussion Despite the non-significant findings, further research is required for the evaluation of LPS-stimulated ICC expression as biomarkers of depressive symptoms
Disciplinas: Medicina
Palabras clave: Psiquiatría,
Neurología,
Depresión,
Fisiopatología,
Inflamación,
Citocinas intracelulares,
Lipopolisacáridos,
Ancianos
Keyword: Psychiatry,
Neurology,
Depression,
Physiopathology,
Inflammation,
Intracellular cytokines,
Lipopolysaccharides,
Aged
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