| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000416626 |
| ISSN: | 1665-2681 |
| Autores: | Wai-Sun Wong, Vincent1 Lai-Hung Wong, Grace1 Mei-Ling Chim, Angel1 Chiu-Wing Chu, Winnie2 Ka-Wai Yeung, David3 Chi-To Li, Kevin1 Lik-Yuen Chan, Henry1 |
| Instituciones: | 1The Chinese University of Hong Kong, Department of Medicine and Therapeutics, Hong Kong. China 2The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, Hong Kong. China 3The Chinese University of Hong Kong, Department of Clinical Oncology, Hong Kong. China |
| Año: | 2013 |
| Periodo: | Mar-Abr |
| Volumen: | 12 |
| Número: | 2 |
| Paginación: | 256-262 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | Probiotics have profound effect on nonalcoholic steatohepatitis (NASH) in animal models. We aimed to test the hypothesis that probiotics treatment was superior to usual care in reducing liver fat in NASH patients. Material and methods. Patients with histology-proven NASH were randomized to receive probiotics (n = 10) or usual care (n = 10) for 6 months. The Lepicol probiotic formula contained Lactobacillus plantarum, Lactobacillus deslbrueckii, Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacterium bifidum. The primary endpoint was change in intrahepatic triglyceride content (IHTG), as measured by proton-magnetic resonance spectroscopy, from baseline to month 6. Secondary endpoints included changes in liver biochemistry and metabolic profile. Results. IHTG decreased from 22.6 ± 8.2% to 14.9 ± 7.0% in the probiotic group (P = 0.034) but remained static in the usual care group (16.9 ± 6.1% to 16.0 ± 6.6%; P = 0.55). Six subjects in the probiotic group had IHTG reduced by more than 30% from baseline, compared to 2 subjects in the usual care group (P = 0.17). The probiotic group also had greater reduction in serum aspartate aminotransferase level (P = 0.008). On the other hand, the use of probiotics was not associated with changes in body mass index, waist circumference, glucose and lipid levels. Conclusions. Probiotics treatment may reduce liver fat and AST level in NASH patients. The therapeutic potential of probiotics in NASH should be tested in larger studies |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Terapéutica y rehabilitación, Metabolismo y nutrición, Hígado graso, Obesidad, Probióticos, Prebióticos |
| Keyword: | Gastroenterology, Therapeutics and rehabilitation, Metabolism and nutrition, Fatty liver, Obesity, Probiotics, Prebiotics |
| Texto completo: | Texto completo (Ver PDF) |
