| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000409383 |
| ISSN: | 1665-2681 |
| Autores: | Branco, Fernanda1 Alencar, Regiane S.M2 Volt, Fernanda1 Sartori, Giovana1 Dode, Andressa1 Kikuchi, Luciana2 Tani, Claudia M2 Chagas, Aline L2 Pfiffer, Tulio2 Hoff, Paulo2 Carrilho, Flair J2 Alves de Mattos, Angelo1 |
| Instituciones: | 1Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil |
| Año: | 2017 |
| Periodo: | Mar-Abr |
| Volumen: | 16 |
| Número: | 2 |
| Paginación: | 263-268 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Estadística o encuesta |
| Enfoque: | Analítico |
| Resumen en inglés | Presence of dermatologic reaction as an adverse event to sorafenib treatment in patients with unresectable hepatocellular carcinoma has been indicated as a prognostic factor for survival in a recent prospective analysis. To date, this is the only clinical predictor of treatment response, which can be evaluated earlier in the treatment and, therefore, contribute to a better and more individualized patient management. Material and methods. This retrospective study included 127 patients treated with sorafenib under real-life practice conditions in two hepatology reference centers in Brazil. Demographic data, disease/medical history and time of sorafenib administration as well as adverse events related to the medication were recorded in a database. Results. Cirrhosis was sults. present in 94% of patients, 85.6% were Child-Pugh A, 80.3%BCLC-C, 81% had vascular invasion and/or extrahepatic spread and 95% had a performance status 0 to 1.The median duration of treatment was 10.1 months (range: 0.1-47 months). The most common adverse event within the first 60 days of treatment were diarrhea (62.2%) and dermatological reaction (42%).The median overall survival for the cohort was 20 months, and it was higher for patients who developed dermatological reactions within the first 60 days compared to those who did not present this adverse event. Conclusion. This retrospective analysis showed the use of sorafenib in patients selected according to BCLC staging, and it is the first external validation of early dermatologic adverse events as a predictor of overall survival in patients with advanced hepatocellular carcinoma |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Gastroenterología, Oncología, Carcinoma hepatocelular, Sobrevivencia, Sorafenib, Efectos adversos, Manifestaciones cutáneas |
| Keyword: | Medicine, Dermatology, Gastroenterology, Oncology, Hepatocellular carcinoma, Survival, Sorafenib, Adverse effects, Cutaneous manifestations |
| Texto completo: | Texto completo (Ver PDF) |
