Interaction of gender and hepatitis C in risk of chronic renal failure after liver transplantation



Título del documento: Interaction of gender and hepatitis C in risk of chronic renal failure after liver transplantation
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000409344
ISSN: 1665-2681
Autores: 1
2
2
2
1
1
1
Instituciones: 1University of British Columbia, Department of Medicine, Vancouver, Columbia Británica. Canadá
2University of British Columbia, Faculty of Pharmaceutical Sciences, Vancouver, Columbia Británica. Canadá
Año:
Periodo: Mar-Abr
Volumen: 16
Número: 2
Paginación: 230-235
País: México
Idioma: Inglés
Tipo de documento: Estadística o encuesta
Enfoque: Analítico
Resumen en inglés Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated. Objectives. To examine the risk factors in the development of CRF in these patients. Material and methods. Material and methods. Retrospective case-cohort of liver transplant patients without baseline kidney dysfunction who developed chronic renal failure during their follow-up. Results. Of 370 patients, 254 met the inclusion criteria. 30% (76) of these patients had CRF of which 57% (43) were male. Age, estimated glomerular filtration rate (eGFR) at discharge, and HCV infection were found to be risk factors for CRF post-LT. The odds ratio of developing CRF was 1.4 (0.6-3.3) in males with HCV, 1.6 (0.7-3.9) in females without HCV and 4.4 (1.5-13.2) among females with HCV when compared to men without HCV. Conclusions. In this cohort of LT receipients of a major Canadian city, age, eGFR, and HCV infection were risk factors for CRF. Female gender and HCV increased this odds by a factor of more than 4
Disciplinas: Medicina
Palabras clave: Gastroenterología,
Nefrología,
Hígado,
Trasplantes,
Insuficiencia hepática,
Calcineurina,
Inhibidores,
Género,
Pronóstico,
Factores de riesgo
Keyword: Medicine,
Gastroenterology,
Nephrology,
Liver,
Transplantation,
Renal failure,
Calcineurin,
Inhibitors,
Gender,
Prognosis,
Risk factors
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