| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000412849 |
| ISSN: | 1665-2681 |
| Autores: | Zhang Wenfeng1 Wu Yakun1 Mu Di1 Gong Jianping1 Wu Chuanxin1 Huang Chun1 |
| Instituciones: | 1Chongqing Medical University, Second Affiliated Hospital, Chongquing, Sichuan. China |
| Año: | 2014 |
| Periodo: | Sep-Oct |
| Volumen: | 13 |
| Número: | 5 |
| Paginación: | 489-495 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Revisión bibliográfica |
| Enfoque: | Analítico |
| Resumen en inglés | Non-alcoholic fatty liver disease (NAFLD) is considered to be a manifestation of liver metabolic damage and is related to insulin resistance and genetic susceptibility. Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in NAFLD is considered to be the perturbation of the C-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) pathways as a result of lipopolysaccharide (LPS) recognition by Toll-like receptor 4 (TLR4). Simultaneously, the activation of NFκB, as mediated by oxidative and endoplasmic reticulum (ER) stress and free fatty acid (FFA) or free cholesterol (FC) crystal formation, heavily relies on NF-κB regulatory factors and TLR4. Additionally, the imbalance of certain pro-inflammatory cytokines and chemokines released by innate immunity is deemed to promote the steatosis of hepatocytes. In conclusion, this review indicates that the inflammatory and oxidative stress of KCs play a significant role in the development of NAFLD |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Bioquímica, Biología celular, Hígado graso no alcohólico, Estrés oxidativo, Inflamación, Células de Kupffer |
| Keyword: | Medicine, Gastroenterology, Biochemistry, Cell biology, Non alcoholic fatty liver, Oxidative stress, Inflammation, Kupffer cells |
| Texto completo: | Texto completo (Ver PDF) |
