| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000407479 |
| ISSN: | 1665-2681 |
| Autores: | Thomas Dupont, Pablo1 Remes Troche, José M1 Izaguirre Hernández, Irma Y1 Sánchez Vargas, Luis A1 Maldonado Rentería, Mathywz de J1 Hernández Flores, Karina G1 Torre, Aldo2 Bravo Sarmiento, Elidé3 Vivanco Cid, Héctor1 |
| Instituciones: | 1Universidad Veracruzana, Instituto de Investigaciones Médico-Biológicas, Veracruz. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Gastroenterología, Ciudad de México. México 3Centro Estatal de la Transfusión Sanguínea, Boca del Río, Veracruz. México |
| Año: | 2016 |
| Periodo: | Jul-Ago |
| Volumen: | 15 |
| Número: | 4 |
| Paginación: | 550-558 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver in which the immunological mechanisms involved in tissue destruction and/or repair are still unclear. Different pro-inflammatory cytokines have been shown to play a determinant role in AIH pathogenesis. Here, we aim to compare the circulating levels of pro- and anti-inflammatory cytokines such as IL-6, TNF-α, IL-17A/F, IL-21, IL-22, IL-23, and IL-10 in patients with type 2 AIH compared to patients with type 1 AIH and healthy controls (HC). Fourty-six Mexican patients with AIH were recruited in our study. Patients were classified as type 1 or 2 AIH based on immune serological markers. Fourty-four serum samples from healthy individuals were included as controls. Serum cytokine levels were determined by ELISA technique. Results. Results.Results. Compared to healthy controls, serum levels of IL-17F, IL-21, IL-23, IL-10, IL-6, and TNF-α, but not IL-17A and IL-22, were significantly increased in AIH patients. When patients were grouped by aminotransferase activity, a biomarker of active disease, a positive correlation between serum IL-17F and alanine transaminase (rs: 0.4739; P = 0.0009) and aspartate transaminase (rs: 0.4984; P = 0.0004) levels was found. A cytokine signature profile associated with type 2 AIH was characterized by high serum IL-21 (type 1 AIH: 0.66 pg/mL; type 2 AIH: 331.1 pg/mL; P = 0.0042) and IL-22 (type 1 AIH: 0.1 pg/mL; type 2 AIH: 55.26 pg/mL; P = 0.0028) levels. Conclusions. We show for the first time, differential regulation of certain pro-inflammatory cytokines associated with disease progression and AIH type in Mexican patients |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Inmunología, Hepatitis autoinmune, Inflamación, Citocinas, Interleucinas |
| Keyword: | Medicine, Gastroenterology, Immunology, Autoimmune hepatitis, Inflammation, Cytokines, Interleukins |
| Texto completo: | Texto completo (Ver PDF) |
