| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000407476 |
| ISSN: | 1665-2681 |
| Autores: | Fan, Jia-Hao1 Hou, Si-Hui1 Li, Qing-Ling2 Hu, Jun1 Peng, Hong1 Guo, Jin-Jun1 |
| Instituciones: | 1Chongqing Medical University, The Second Affiliated Hospital, Chongquing, Sichuan. China 2Chongqing Medical University, Institute of Life Sciences, Chongquing, Sichuan. China |
| Año: | 2016 |
| Periodo: | Jul-Ago |
| Volumen: | 15 |
| Número: | 4 |
| Paginación: | P-P |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Leukocyte antigen DQ (HLA-DQ) and interferon-λ4 (IFNL4) gene polymorphisms were associated with susceptibility to chronic hepatitis B and C virus infection. This study further confirmed that variants of these genes were associated with susceptibility and spontaneous clearance of HBV infection in a Chinese population. Material and methods. Material and methods. Material and methods. A total of 1,069 subjects were recruited and divided into three groups i.e. 397 with CLD (HBV-related chronic liver disease), 434 with SC (spontaneous clearance), and 238 HC (healthy controls). HLA-DQrs9275319 and IFNL4rs368234815, rs12971396, rs12979860, and rs8099917SNPs were genotyped using the Sequenom MassARRAY MALDI-TOF system. Results. Results. Results. HLA-DQ rs9275319 showed a significant association with HBV infection (allele model, OR, 0.514; 95% CI, 0.359-0.738, adjusted p = 0.0003) and with natural clearance (allele model, OR, 1.659; 95% CI, 1.197-2.300, adjusted. However, there was no association between IFNL4 polymorphism and HBV susceptibility or natural clearance (all p > 0.05). The multifactor dimensionality reduction (MDR) test with permutation correction showed that a three-way interaction between IFNL4 and HLA-DQ SNPs was identified for HBV susceptibility (permutation p = 0.009 for the best factor model) and clearance (permutation p = 0.014 for the best factor model). Conclusions. Conclusions. The data from the current study provided additional evidence for an SNP-SNP interaction between HLA-DQ and IFNL4 in regulation to HBV infection and natural clearance |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Virus de la hepatitis B, Antígeno leucocitario humano, Interferón, Polimorfismos de nucleótido único (SNPs), Riesgo de infección, Infecciones virales |
| Keyword: | Medicine, Gastroenterology, Hepatitis B virus, Human leukocyte antigen, Interferon, Single nucleotide polymorphism (SNPs), Infection risk, Viral infections |
| Texto completo: | Texto completo (Ver PDF) |
