| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000435798 |
| ISSN: | 0001-3765 |
| Autores: | Cunha, Eduardo B.B1 Silva, Natália F. da2 Lima, Jean de3 Serrato, Julia A1 Aita, Carlos A.M4 Herai, Roberto H1 |
| Instituciones: | 1Pontificia Universidade Catolica do Parana, Programa de Pos-graduacao em Ciencias da Saude, Curitiba, Parana. Brasil 2Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil 3Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Sao Paulo. Brasil 4Laboratorio Diagnosticos Brasil, Sao Jose dos Pinhais, Parana. Brasil |
| Año: | 2020 |
| Volumen: | 92 |
| Número: | 4 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Atherosclerosis is caused by a monocyte-mediated inflammatory process that, in turn, is stimulated by cytokines and adhesion molecules. Monocytes are then differentiated into macrophages, leading to the formation of arterial atherosclerotic plaques. Recently, guavirova leaf extracts from Campomanesia xanthocarpa (EG) have shown potential effects on the treatment of plaque formation by reducing cholesterol, LDL levels and serum oxidative stress. We evaluated the effect of EG on the viability of human monocytic and endothelial cell lines at three time points (24, 48 and 72 hours) and whether it can modulate the migration and in vitro expression of CD14, PECAM-1, ICAM-1, HLA-DR and CD105. Cell viability was affected only at higher concentrations and times. We observed decreased ICAM-1 expression in cells treated with 50 μg/ml EG and CD14 expression with IFN-γ and without IFN-γ. CD14 also decreased endothelial cell expression in the presence of IFN-γ and GE. We also found decreased expression of PECAM-1 when treated with EG and IFN-γ. In addition, EG-treated endothelial cells showed higher migration than the control group. Reduced expression of these markers and increased migration may lead to decreased cytokines, which may be contributing to decreased chronic inflammatory response during atherosclerosis and protecting endothelial integrity |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Sistema cardiovascular, Aterosclerosis, Extractos vegetales, Campomanesia xanthocarpa, Myrtaceae |
| Keyword: | Cardiovascular system, Atherosclerosis, Plant extracts, Campomanesia xanthocarpa, Myrtaceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
