| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000412269 |
| ISSN: | 0001-3765 |
| Autores: | Pinto, Maria E.A1 Araujo, Sthefane G1 Morais, Marcela I1 Sa, Nivea P2 Lima, Caroline M2 Rosa, Carlos A2 Siqueira, Ezequias P3 Johann, Susana2 Lima, Luciana A.R.S1 |
| Instituciones: | 1Universidade Federal de Sao Joao del Rei, Campus Centro-Oeste Dona Lindu, Divinopolis, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 3Fundacao Instituto Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2017 |
| Periodo: | Sep |
| Volumen: | 89 |
| Número: | 3 |
| Paginación: | 1671-1682 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Farmacología, Fitoquímica, Aceites vegetales, Acidos grasos, Actividad antioxidante, Actividad antifúngica |
| Keyword: | Medicine, Chemistry, Pharmacology, Phytochemistry, Plant oils, Fatty acids, Antioxidant activity, Antifungal activity |
| Texto completo: | Texto completo (Ver HTML) |
