| Revista: | Anais brasileiros de dermatologia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000460461 |
| ISSN: | 0365-0596 |
| Autores: | Miot, Hélio Amante1 Criado, Paulo Ricardo2 Castro, Caio César Silva de3 Ianhez, Mayra4 Talhari, Carolina5 Ramos, Paulo Müller1 |
| Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo. Brasil 2Faculdade de Ciencias Medicas de Santos, Santos, Sao Paulo. Brasil 3Hospital de Dermatologia Sanitaria do Parana, Curitiba, Parana. Brasil 4Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Goiania, Goias. Brasil 5Universidade do Estado do Amazonas, Departamento de Dermatologia, Manaus, Amazonas. Brasil |
| Año: | 2023 |
| Volumen: | 98 |
| Número: | 5 |
| Paginación: | 656-677 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The JAK-STAT signaling pathway mediates important cellular processes such as immune response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that interfere with different JAK-STAT signaling patterns have potential indications for various medical conditions. The main dermatological targets of JAK-STAT pathway inhibitors are inflammatory or autoimmune diseases such as psoriasis, vitiligo, atopic dermatitis and alopecia areata; however, several dermatoses are under investigation to expand this list of indications. As JAK-STAT pathway inhibitors should gradually occupy a relevant space in dermatological prescriptions, this review presents the main available drugs, their immunological effects, and their pharmacological characteristics, related to clinical efficacy and safety, aiming to validate the best dermatological practice |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Terapéutica, Alopecia areata, Dermatitis atópica, Psoriasis, Vitiligo, Inhibidores enzimáticos, Janus quinasa |
| Keyword: | Dermatology, Therapeutics, Alopecia areata, Atopic dermatitis, Psoriasis, Vitiligo, Enzyme inhibitors, Janus Kinase |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
