| Revista: | Anais brasileiros de dermatologia |
| Base de datos: | |
| Número de sistema: | 000558099 |
| ISSN: | 0365-0596 |
| Autores: | Drummond, Marina Rovani1 Santos, Luciene Silva dos1 Souza, Lais Bomediano3 Mitsuushi, Gabriela Nero1 Cintra, Maria Letícia2 França, Andrea Fernandes Eloy da Costa1 Souza, Elemir Macedo de1 Velho, Paulo Eduardo Neves Ferreira1 |
| Instituciones: | 1Universidade Estadual de Campinas, School of Medical Sciences, São Paulo. Brasil 2Universidade Estadual de Campinas, School of Medical Sciences, São Paulo, São Paulo. Brasil 3Pontifícia Universidade Católica de Campinas, Department of Medicine, São Paulo, São Paulo. Brasil |
| Año: | 2023 |
| Periodo: | Jul-Ago |
| Volumen: | 98 |
| Número: | 4 |
| Paginación: | 472-479 |
| País: | Brasil |
| Idioma: | Inglés |
| Resumen en inglés | Background: Livedoid vasculopathy (LV) manifests as ulcers and atrophic white scars on the lower extremities. The main known etiopathogenesis is hypercoagulability with thrombus formation, followed by inflammation. Thrombophilia, collagen and myeloproliferative diseases may induce LV, but the idiopathic (primary) form predominates. Bartonella spp. may cause intra-endothelial infection and skin manifestations caused by these bacteria may be diverse, including leukocytoclastic vasculitis and ulcers. Objective: The aim of this study was to investigate the presence of bacteremia by Bartonella spp. in patients with difficult-to-control chronic ulcers diagnosed as primary LV. Methods: Questionnaires and molecular tests (conventional PCR, nested PCR and real-time PCR) were applied and liquid and solid cultures were performed in the blood samples and blood clot of 16 LV patients and 32 healthy volunteers. Results: Bartonella henselae DNA was detected in 25% of LV patients and in 12.5% of control subjects but failed to reach statistically significant differences (p = 0.413). Study limitations: Due to the rarity of primary LV, the number of patients studied was small and there was greater exposure of the control group to risk factors for Bartonella spp. infection. Conclusion: Although there was no statistically significant difference between the groups, the DNA of B. henselae was detected in one of every four patients, which reinforces the need to investigate Bartonella spp. in patients with primary LV. |
| Keyword: | Bartonella, Livedoid vasculopathy, Skin ulcer |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
