| Revista: | Acta scientiarum. Biological sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000433537 |
| ISSN: | 1679-9283 |
| Autores: | Morais, Daniel Vieira de1 Moreira, Manuela Maria2 Silva, Fabiane de Lima3 Costa, Maria Angélica Pereira de Carvalho3 Delerue-Mato, Cristina2 Carvalho, Carlos Alfredo Lopes de3 Estevinho, Maria Leticia Miranda4 |
| Instituciones: | 1Universidade de Sao Paulo, Centro de Energia Nuclear na Agricultura, Piracicaba, Sao Paulo. Brasil 2Instituto Superior de Engenharia do Porto, Rede de Quimica e Tecnologia, Laboratorio Associado para a Quimica Verde, Porto. Portugal 3Universidade Federal do Reconcavo da Bahia, Centro de Ciencias Agrarias, Ambientais e Biologicas, Cruz das Almas, Bahia. Brasil 4Instituto Politecnico de Braganca, Centro de Investigacao de Montanha, Braganca. Portugal |
| Año: | 2019 |
| Volumen: | 41 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | For the first time, the anti-hemolytic activity and the enzyme inhibitory activities of Dalbergia ecastaphyllum leaves extracts were tested against α-amylase, α-glucosidase, lipase, acetylcholinesterase, butyrylcholinesterase, tyrosinase and hyaluronidase. The phenolic profile of the obtained extracts was also investigated by high-performance liquid chromatography with photodiode array detection (HPLC-PAD). The extracts showed inhibitory activity against all enzymes evaluated, with the highest inhibitory activity reported for the enzyme hyaluronidase (28.28 ± 2.43 to 72.19 ± 1.40 μg mL-1). The obtained extracts also demonstrate anti-hemolytic activity (52.22 ± 1.62 to 71.17 ± 1.82%). Among the phenolic compounds identified, protocatechuic, vanillic and β-resorcylic acids were the most abundant (1.13 ± 0.06 to 2.53 ± 0.06, 0.90 ± 0.06 to 2.19 ± 0.06 and 1.03 ± 1.62 to 22.11 ± 1.62 mg L-1, respectively). In the statistical analysis, a significant correlation was found between the flavonoids content and all enzymes inhibitory activities. The present study showed that D. ecastaphyllum leaves extracts may have the potential to be used in the therapeutic treatment of several diseases such as Alzheimer, Parkinson, type 2 diabetes mellitus, hyperglycemia, and pigmentation, as well as those associated with oxidative stress |
| Disciplinas: | Biología, Química, Medicina |
| Palabras clave: | Angiospermas, Fitoquímica, Farmacología, Extractos vegetales, Ensayos clínicos, Acetilcolinesterasa, Alfa-glucosidasa, Hialuronidasa, Actividad enzimática, Dalbergia ecastaphyllum, Fabaceae |
| Keyword: | Angiosperms, Phytochemistry, Pharmacology, Plant extracts, Clinical assays, Acetylcholinesterase, Alpha-glycosidase, Hyaluronidase, Enzymatic activity, Dalbergia ecastaphyllum, Fabaceae |
| Texto completo: | http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/46622/751375148692 |
