| Revista: | Acta cirurgica brasileira |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000286067 |
| ISSN: | 0102-8650 |
| Autores: | Martins, Antonio Carlos Pereira1 Britto, Sergio Takata, Clecio Tucci-Junior, Silvio Borelli-Bovo, Tiago Jose Dias-Neto, Jose Anastacio |
| Instituciones: | 1Universidade de Sao Paulo, Faculdade de Medicina, Ribeirao Preto, Sao Paulo. Brasil |
| Año: | 2002 |
| Volumen: | 17 |
| Paginación: | 12-14 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | OBJECTIVE: To investigate microvessel density as a risk factor in squamous cell carcinoma of the penis. METHODS: Fifty patients with penile carcinoma were evaluated retrospectively. The mean age and standard deviation were 60.8±11.8 years. All of them were treated by penectomy and with positive nodes underwent groin lymphadenectomy. Tumor grading was 36 G1 and 24 G2/3. Primary lesion stage was 22 pT1 and 28 pT2-4. Positive inguinal nodes were observed in 18 patients. Selected paraffin embedded sections were submitted to CD34 immunohistochemical analysis by the avidin-biotin-immunoperoxidase method with antigen retrieval. All slides were examined using an automatic analyzer system and the number of micro-vessels in 10 high magnification power fields (400X) were counted in a blind analysis. RESULTS: Median number of microvessels was 631 in G1 versus 695 in G2/3 tumors (p=0.78), and 696 in pT1 versus 566 pT2-4 tumors (p=0.23). The respective data for pN0 patients was 525 and for pN+ was 696 (p=0.01), which is an unexpected result. CONCLUSION: CD34 immunoexpression or microvessel density determined by this method bear no association with tumor grade, stage or prognosis |
| Disciplinas: | Medicina |
| Palabras clave: | Cirugía, Diagnóstico, Oncología, Carcinoma, Pene, Células escamosas, Marcadores tumorales, Linfadenectomía |
| Keyword: | Medicine, Diagnosis, Oncology, Surgery, Squamous cells, Carcinoma, Penis, Tumor markers, Lymphadenectomy |
| Texto completo: | Texto completo (Ver HTML) |
