| Revista: | The journal of venomous animals and toxins |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298724 |
| ISSN: | 0104-7930 |
| Autores: | Bagchi, S1 Deshpande, S.B |
| Instituciones: | 1Banaras Hindu University, Institute of Medical Sciences, Varanasi, Banaras. India |
| Año: | 2001 |
| Volumen: | 7 |
| Número: | 1 |
| Paginación: | 25-44 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The mechanisms underlying the action of Indian red scorpion Buthus tamulus (BT) venom-induced augmentation of cardiopulmonary reflexes elicited by intravenous injection of 5-HT were examined in urethane anaesthetized rats. The 5-HT produced a concentration-dependent increase in time-response area of bradycardiac response, with the responses at submaximal concentrations shifted to the left after exposure to BT venom (20 µg/kg, IV). Aprotinin (6000 kallikrein inactivating unit, IV) as such had no effect on 5-HT reflex responses (bradycardia, hypotension, and apnea), but blocked the venom-induced reflex augmentation. While ondansetron (10 µg/kg, IV) completely blocked the 5-HT reflex responses, these reappeared partially after venom exposure (20 µg/kg). Exposure to bradykinin (50 µg/kg, IV) for 30 min also augmented the 5-HT-induced reflex responses similar to venom. The bradykinin-induced augmentation was also blocked by ondansetron. Results indicate that the venom-induced augmentation of cardiopulmonary reflexes is mediated through kinins sensitizing 5-HT3 receptor subtypes |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Toxicología, Bioquímica, Veneno de alacrán, Toxicidad, Aprotinina, Bradiquinina, Ondansetrón, Reflejo de Bezold-Jarisch, Kininas, Buthus tamulus, Buthidae |
| Keyword: | Medicine, Cardiovascular system, Toxicology, Biochemistry, Scorpion venom, Toxicity, Aprotinin, Bradykinin, Ondansetron, Bezold-Jarisch reflex, Kinins, Buthus tamulus, Buthidae |
| Texto completo: | Texto completo (Ver HTML) |
