| Revista: | The journal of venomous animals and toxins |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298636 |
| ISSN: | 0104-7930 |
| Autores: | Lipps, B.V1 |
| Instituciones: | 1Ophidia Products Inc., Houston, Texas. Estados Unidos de América |
| Año: | 1999 |
| Volumen: | 5 |
| Número: | 2 |
| Paginación: | 172-183 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Cancer cell inhibitors, named Atroporin and Kaotree, having molecular weights of 35 kDa and 6 kDa have been isolated from the venoms of Crotalus atrox and Naja naja kaouthia, respectively, by fractionation on high pressure liquid chromatography. The purified Atroporin and Kaotree showed killing effects on various types of human (breast, colon, liver, ovary, etc.) and animal cancer cells in concentrations as low as 0.5µg/ml, and having no effect on normal mouse kidney, liver, spleen, and erythrocytes up to 5.0µg/ml. Both Atroporin and Kaotree prevent the formation of ascitic tumors caused by myeloma cells in Balb/C mice. In addition, both Atroporin and Kaotree showed regression of ascitic tumors formed by myeloma cells. Atroporin and Kaotree complement each other, as in combination they showed elevated anti-cancer activity in vitro and in vivo systems. However, Atroporin and Kaotree are immunologically distinct proteins showing no cross reactivity. Atroporin and Kaotree, individually or in combination, have the potential for cancer biotherapy |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Oncología, Bioterapia, Células cancerosas, Veneno de víbora, Proteínas, Citólisis |
| Keyword: | Medicine, Experimental medicine, Oncology, Biotherapy, Cancer cells, Snake venom, Proteins, Cytolysis |
| Texto completo: | Texto completo (Ver HTML) |
