| Revista: | The journal of venomous animals and toxins |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298734 |
| ISSN: | 0104-7930 |
| Autores: | Rahmy, T.R1 |
| Instituciones: | 1United Arab Emirates University, Faculty of Science, Al-Ain. Emiratos Arabes Unidos |
| Año: | 2001 |
| Volumen: | 7 |
| Número: | 1 |
| Paginación: | 85-112 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The effect of intramuscular (IM) injection of a sub-lethal dose of Naja haje cobra venom (0.015 mug/gm body weight) on the ultrastructure of renal cortical tissues of rabbits was studied at different time intervals after envenomation. Succinic dehydrogenase (SDH) enzyme activity was also detected in the renal cortical tubules. Three hours after venom injection, slight changes were seen in visceral cells and glomerular endothelia. The cortical tubular epithelia revealed an increase of lysosomal structures, cytoplasmic vacuolization, and nuclear irregularity. Severe ultrastructural changes were recorded 6 hours after envenomation, including hypertrophied parietal cells, blebbed visceral epithelial cells, and foot process disorganization. Dilated glomerular capillaries lined by hypertrophied endothelial cells and signs of mesangiolysis were also observed. The proximal tubular epithelia showed vesiculated endoplasmic reticulum and numerous lysosomal vacuoles, while the distal tubular epithelia were mostly necrotic. These alterations were more intense 12 hours after venom injection. Parietal and visceral cells showed similar changes to those of the six-hour group. Most of the glomerular endothelial cells lost their integrity and diffused into the capillary lumen. Mesangiolysis was also observed. The proximal tubular epithelial cells revealed severely affected cellular organelles, dilated brush borders, disruption of the basal membrane infoldings, and cellular necrosis. The distal tubular epithelia lost most of their cytoplasmic electron |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Toxicología, Veneno de víbora, Nefrotoxicidad, Naja haje, Elapidae |
| Keyword: | Medicine, Experimental medicine, Toxicology, Snake venom, Nephrotoxicity, Naja haje, Elapidae |
| Texto completo: | Texto completo (Ver HTML) |
