Absence of seasonal effect on the immunomodulatory action of brazilian propolis on natural killer activity



Título del documento: Absence of seasonal effect on the immunomodulatory action of brazilian propolis on natural killer activity
Revista: The journal of venomous animals and toxins
Base de datos: PERIÓDICA
Número de sistema: 000298748
ISSN: 0104-7930
Autores: 1

Instituciones: 1Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Botucatu, Sao Paulo. Brasil
Año:
Volumen: 8
Número: 1
Paginación: 19-29
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental
Resumen en inglés Propolis, a beehive product widely used in folk medicine as an antiinflammatory agent, has been attracting researchers' attention to scientifically elucidate its biological properties and therapeutic activities. The aim of this paper was to study the possible effect of propolis on natural killer activity, since propolis immunomodulatory action has been suggested, especially on non-specific immunity. Propolis was produced by africanized honeybees (Apis mellifera L.), collected throughout a whole year, and pooled by season. Hydroalcoholic solutions of propolis were prepared with each pool and administered to rats by gavage over three days. Natural killer activity of non-adherent spleen cells was evaluated by the 51Cr-release cytotoxicity assay against Yac-1 target cells. Our results indicated that the natural killer activity was increased in spleen cells from propolis-treated animals. There were no significant differences related to the seasonal effect on the immunomodulatory action of propolis
Disciplinas: Biología
Palabras clave: Inmunología,
Propóleo,
Inmunomodulación,
Ensayos de citotoxicidad
Keyword: Biology,
Immunology,
Propolis,
Immunomodulation,
Cytotoxic assays
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