Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite
Título del documento: Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite
Revista: The journal of venomous animals and toxins including tropical diseases
Base de datos: PERIÓDICA
Número de sistema: 000298956
ISSN: 1678-9199
Autores: 1
Instituciones: 1Bawaskar Hospital and Research Center, Maharashtra. India
Año:
Volumen: 12
Número: 1
Paginación: 137-141
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico, descriptivo
Resumen en inglés Snake antivenom is a specific antidote to the venom action, neutralizing the circulating venom. However, it fails to neutralize the venom fixed to target organs such as platelets, renal tubules, etc. Russell's viper venom initiates rapid coagulation in a victim by activating blood platelets, factors V, X, and anticoagulant cofactors. Activation of thrombin, resulting in formation of micro-thrombi, fibrinolysis, and a vicious cascade, sets in. Inhibition of activated platelets by aspirin (cyclooxygenase inhibitor) and clopidogrel (ADP receptor inhibitor) helps to break this vicious circle induced by Russell's venom and may initiate the natural physiological clotting mechanism. They can be utilized as an adjuvant treatment
Disciplinas: Medicina
Palabras clave: Farmacología,
Hematología,
Toxicología,
Veneno de víbora,
Fibrinólisis,
Coagulación sanguínea,
Aspirina,
Clopidogrel,
Daboia russelli,
Viperidae
Keyword: Medicine,
Hematology,
Pharmacology,
Toxicology,
Snake venom,
Fibrinolysis,
Blood coagulation,
Aspirin,
Clopidogrel,
Daboia russelli,
Viperidae
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