| Revista: | The journal of venomous animals and toxins including tropical diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298926 |
| ISSN: | 1678-9199 |
| Autores: | Albas, A1 Fontolan, O.L2 Pardo, P.E3 Bremer-Neto, H Sartori, A |
| Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Botucatu, Sao Paulo. Brasil 3Universidade do Oeste Paulista, Faculdade de Medicina Veterinaria, Presidente Prudente, Sao Paulo. Brasil |
| Año: | 2006 |
| Volumen: | 12 |
| Número: | 3 |
| Paginación: | 476-486 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | In this study, we compared the levels of neutralizing antibodies induced by inactivated rabies vaccine in cattle by using three alternative immunization procedures. Forty-five bovines (breed nelore) were then organized in three groups (A, B and C, with 15 animals/group). Group A received only one vaccine dose at day zero and Group B received the first dose at day zero and then another dose at day 30 (early booster). Group C was also immunized with two doses; however, the booster was postponed until day 180 after the first dose (delayed booster). Blood samples were withdrawn at days zero (before the first dose) and 30, 210, 390, and 540 after the beginning of immunization and the antibody titers were evaluated by mouse neutralization test. The protocol used to immunize Group C (booster at day 180) was clearly more efficient. In this group, antibody levels were higher and also remained higher for longer periods in comparison with the other two groups. These results show that booster timing significantly affected antibody levels. Therefore, programs addressed to control this disease in cattle should consider not only the use of a booster but also its administration time |
| Disciplinas: | Medicina, Medicina veterinaria y zootecnia |
| Palabras clave: | Medicina experimental, Bovinos, Inmunología, Rabia, Vacunas, Anticuerpos |
| Keyword: | Medicine, Veterinary medicine and animal husbandry, Experimental medicine, Bovines, Immunology, Rabies, Vaccines, Antibodies |
| Texto completo: | Texto completo (Ver HTML) |
