| Revista: | The journal of venomous animals and toxins including tropical diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000299006 |
| ISSN: | 1678-9199 |
| Autores: | Achkar, S.M1 Sinhorini, I.L2 Ribeiro, O.G3 Carrieri, M.L Ceretta, R.S Consales, C.A |
| Instituciones: | 1Instituto Pasteur, Sao Paulo. Brasil 2Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil 3Instituto Butantan, Laboratorio de Inmunogenetica, Sao Paulo. Brasil |
| Año: | 2007 |
| Volumen: | 13 |
| Número: | 1 |
| Paginación: | 39-55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Rabies is a severe and lethal disease that produces a slight inflammatory response during the infection process. We analyzed the immunopathological mechanisms that occur in the central nervous system (CNS) using mice genetically selected for maximal or minimal acute inflammatory reaction (AIRmax or AIRmin). As viral samples, we adopted the antigenic variant 3 (AgV3) of rabies virus from hematophagous bats and a fixed virus strain (PV1 43/3). Titration of specific antibodies was performed using enzyme-linked immunosorbent assay (ELISA). We observed a slight increase in IgG and IgG1 isotypes in infected AIRmax mice. Incubation period, determined by intracerebral inoculation with 100 LD50, was 6-7 days for PV1 43/4 strain and 9-10 days for AgV3. No difference in viral replication was noticed between AIRmax and AIRmin mice. Mortality was 100% with both viral strains. Histopathological analysis of brains and spinal cords showed inflammatory foci in all regions of the CNS. No differences were noticed in the number of neutrophils. Negri bodies were observed in practically all sites analyzed. Results suggested that inflammatory reaction is not a determining factor in the susceptibility to rabies infection |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Inmunología, Rabia, Replicación viral, Inflamación, Inmunoglobulinas, Isotipos |
| Keyword: | Medicine, Experimental medicine, Immunology, Rabies, Viral replication, Inflammation, Immunoglobulins, Isotypes |
| Texto completo: | Texto completo (Ver HTML) |
