| Revista: | The journal of venomous animals and toxins including tropical diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298931 |
| ISSN: | 1678-9199 |
| Autores: | Abdoon, N.A1 Ali, A.A2 Alnema, A.A Hag-Ali, M3 Fatani, A.J4 |
| Instituciones: | 1King Fahad National Guard Hospital, National Antivenom and Vaccine Production Center, Riyadh. Arabia Saudita 2University of Khartoum, College of Pharmacy, Khartoum. Sudán 3Zayed Military Hospital, Abu Dhabi. Emiratos Arabes Unidos 4King Saud University, College of Pharmacy, Riyadh. Arabia Saudita |
| Año: | 2006 |
| Volumen: | 12 |
| Número: | 3 |
| Paginación: | 374-389 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The cumulative actions of scorpion neurotoxins are complex and may be traced to activation of different ion channels with subsequent release of various transmitters and modulators including inflammatory mediators. This could lead to various pathological manifestations such as acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), and multiple organ failure (MOF). Several approaches have been advocated to treat the multitude of scorpion-venom-elicited pathological changes. However, few have tried to combat the venom-induced effects on the inflammatory process, which manifest as ARDS, SIDS and MOF. Thus, the aim of this study was to determine the capability of inhibitors of different steps of the inflammatory sequence of events in scorpion envenomation to ameliorate the detrimental action of the venom and prolong survival of mice injected with Leiurus quinquestriatus quinquestriatus (LQQ) venom. Animals were divided into groups (n = 10) and given montelukast (10 or 20 mg.kg-1, orally), hydrocortisone (5 or 10 mg.kg-1, intravenously) or indomethacin (10 or 20 mg kg-1, intravenously). Then, all animals were subcutaneously injected with either 0.25 or 0.3 mg.kg-1 LQQ venom. Signs and symptoms of envenomation were recorded and survival percentages after 24 hours as well as survival time were determined in each group. To analyze data, we utilized Covariance Wilcoxon survival statistics and survival distribution curves. In general, when compared to venom alone, administration of montelukast (p<0.001) |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Toxicología, Veneno de escorpión, Síndrome de respuesta inflamatoria sistémica, Síndrome de distrés respiratorio agudo, Falla orgánica múltiple, Montelukast, Hidrocortisona, Indometacina, Leiurus quinquestriatus, Buthidae |
| Keyword: | Medicine, Pharmacology, Toxicology, Scorpion venom, Systemic inflammatory response syndrome, Acute respiratory distress syndrome, Multiple organ failure, Montelukast, Hydrocortisone, Indomethacin, Leiurus quinquestriatus, Buthidae |
| Texto completo: | Texto completo (Ver HTML) |
