| Revista: | The journal of venomous animals and toxins including tropical diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298861 |
| ISSN: | 1678-9199 |
| Autores: | Ferreira, J1 Bastos, M.F2 Pelizon, A.C Peres, C.M Cavalcante, D.P Sartori, A |
| Instituciones: | 1Universidade de Sao Paulo, Instituto de Fisica, Sao Carlos, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Botucatu, Sao Paulo. Brasil |
| Año: | 2005 |
| Periodo: | Sep |
| Volumen: | 11 |
| Número: | 3 |
| Paginación: | 336-349 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Alternative sources of anti-ophidic serum are being investigated due to the secondary effects associated with types I and II hypersensitivity reactions. In the present study we raised and evaluated the protective effect of an ovine antibothropic serum in a Swiss mice envenoming model. Ovine antiserum was obtained by immunization with seven increasing doses of bothropic venom associated with adjuvants. The neutralizing ability was tested by the lethal activity (2 LD50) neutralization and serum and splenic venom levels after antivenom administration to experimentally envenomed mice. The antiserum effect on local edema was also tested by injection of venom/antivenom mixtures into the mice footpads. Ovine antiserum neutralized lethal activity and also significantly decreased serum and splenic venom levels. However, this antiserum was not able to mediate any protective effect on edema triggered by bothropic venom |
| Disciplinas: | Medicina |
| Palabras clave: | Toxicología, Inmunología, Veneno de víbora, Antisuero de oveja, Neutralización, ELISA, Edema, Bothrops jararaca, Viperidae |
| Keyword: | Medicine, Toxicology, Immunology, Snake venom, Sheep antiserum, Neutralization, ELISA, Edema, Bothrops jararaca, Viperidae |
| Texto completo: | Texto completo (Ver HTML) |
