The evolution of the resistance of Staphylococcus aureus found on healthcare workers correlated with local consumption of antibiotics
Título del documento: The evolution of the resistance of Staphylococcus aureus found on healthcare workers correlated with local consumption of antibiotics
Revista: The brazilian journal of infectious diseases
Base de datos: PERIÓDICA
Número de sistema: 000291042
ISSN: 1413-8670
Autores: 1
2
3
Instituciones: 1Universidade Estadual de Ponta Grossa, Ponta Grossa, Parana. Brasil
2Santa Casa de Misericordia de Ponta Grossa, Ponta Grossa, Parana. Brasil
3Universidade Federal do Parana, Curitiba, Parana. Brasil
Año:
Periodo: Jun
Volumen: 10
Número: 3
Paginación: 185-190
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental
Resumen en inglés OBJECTIVE: Correlate the evolution of the resistance of Staphylococcus aureus collected from healthcare workers with the local consumption of antibiotics. MATERIAN AND METHODS: Open prospective research.Study Site. General Reference Hospital with 200 beds in a 700,000 inhabitant region, in Ponta Grossa, Paraná, Brazil. RESULTS: Two collections (samples) of Staphylococcus aureus isolates were obtained from healthcare-workers during an approximate four-year interval. Samples 1 (n= 200) and 2 (n= 270) had this bacterium in 63 (32%) and 90 (33%) of the patients, respectively. At the same time, the annual consumption of antibiotics in DDD/1,000 patient-days was determined. The variation of resistance was significantly smaller (m.s.d.=12.11) for gentamycin (p<0.01) and (m.s.d.=9.22) for Tobramycin (p<0.05). The correlation between variation in resistance and antibiotic consumption was not significant. Workers studied in the two samples showed a significant (p<0.01) frequency (c²=10.44) for persistent nasal carriage and for non carriage. Methicillin resistant Staphylococcus aureus was found in 12 (6%) patients of sample 1 and 11 patients (4%) of sample 2. CONCLUSION: Stability of resistance allows us to maintain therapeutic outlines. The variation in bacterial resistance in the twice-sampled population (n=105) indicated the selection pressure of the hospital environment. The resistance that was found is representative of the hospital microbiota; this relationship represents a biological model, based on the healthcare-workers' int
Disciplinas: Biología,
Medicina
Palabras clave: Bacterias,
Farmacología,
Hospitales,
Microbiología,
Staphylococcus aureus,
Portadores nasales,
Trabajadores de la salud,
Resistencia a antibióticos
Keyword: Biology,
Medicine,
Bacteria,
Hospitals,
Microbiology,
Pharmacology,
Staphylococcus aureus,
Nasal carriers,
Health workers,
Antibiotic resistance
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